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CORRECTION OF A FUNCTIONAL CONDITION OF ATHLETES WITH HERBAL MEDICINES –SORBENTS OF ENDOTOXINS

K. N. NAUMOVA (1), B. M. KERSHENGOLTZ (2), V. V. ANSHAKOVA (1), R. I. PLATONOVA (1) 1-NORTH-EASTERN FEDERAL UNIVERSITY IN YAKUTSK, YAKUTSK , RUSSIA,2-STATE RESEARCH INSTITUTE OF BIOLOGICAL PROBLEMS OF CRYOLITHOZONE OF THE SIBERIAN BRANCH OF RAS, YAKUTSK, RUSSIA
Objective: to study the influence of physical loads on the physiological state of the athlete's body associated with the accumulation of endogenous toxins, to develop a method for reducing their concentration with the help of phytogenic sorbents.
Materials and methods: preclinical studies were performed on mice of the species Mussp. Line CD-1 (n = 20) for 60 days. The animals were divided into experimental (n=10) and control group (n=10). Animals of the experimental group received biological product based on vegetable raw materials (lichen Cladonia and Rhodiola rosea) with gastric tube in the dose of 50 mg/kg daily, the control group received water. On day 30, the animals were tested for motor and research activity, and the lactate and urea concentrations in the blood were analyzed. Further clinical studies were conducted with the participation of athletes of the Russian national combat sport team (n = 10) during 30 days during sparring battles simulating competitive activity. Athletes were divided into two groups: experimental (n=5) and control (n=5). Athletes of the experimental group took a biological product based on vegetable raw materials (lichen Cladonia and Rhodiola rosea) in a dose of one capsule per os between meals, the control group received placebo (powder of ringer-Locke capsules), in the same terms in a similar way. Detoxification property of the biopreparation was assessed by the changing of the content of urea and blood lactate. To assess the degree of adequacy between physical loads and the functional state of the body, the urea concentration in the blood was also measured.
Results: the level of blood lactate in animals of the control group on the 30th day of studies was 11,2 Mmol/l, and in the experimental group – 8,1 Mmol/l. The level of urea on the 60th day of studies in the control group increased by 0,4 Mmol/l, in the experimental group decreased by 1,9 Mmol/l. In athletes of the experimental group, the urea level in the blood increased from 4,2 to 6,2 mMol/l, remaining within the norm (6,4 Mmol/l), and in athletes of the control group, the same index was 9,4 Mmol/l.
Conclusions: the combination of the results of preclinical and clinical studies allows us to conclude that the biological product based on plant raw materials possesses high sorption properties with respect to endotoxins of various nature and eliminates them from the body. Detoxification of the body of athletes has a positive effect on the tolerability of high loads, rapid recovery and improves training.
Keywords: 
endotoxins; highly qualified athletes; martial arts; vegetable sorbent; functional state.