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ASPECTS OF ACTOPROTECTIVE ACTIVITY OF CERTAIN NATURAL COMPOUNDSWITH DIFFERENT CHEMICAL STRUCTURE

A. V. VORONKOV, E. T. OGANESYAN, А. D. GERАSCHENKOPYATIGORSK MEDICAL PHARMACEUTICAL INSTITUTE OF VOLGOGRAD STATE MEDICAL UNIVERSITY, PYATIGORSK, RUSSIA

Objective: the purpose of the present research was the complex assessment of the influence of natural compounds on high-speed characteristics, working capacity, endurance of laboratory mice during physical activities. Materials and methods: actoprotective activity of natural compounds was estimated by the method of shuttle swimming in laboratory mice, anti-hypoxic activity of natural compounds was evaluated on two models: histotoxic and circulatory model.
Results: administration of the ATACL compound increased the high-speed and power characteristics and endurance of laboratory animals and also positively affected both histotoxic and circulatory hypoxia.
Conclusions: study results showed that compounds under he ATACL code had the most profound actoprotective and anti-hypoxic effects in comparison with other studied compounds. At the same time the pharmacological effect of the use of this compound was comparable to that of the use of reference drugs at all stages of the experiment.
Keywords: 
aactoprotectors; shuttle swimming; exercise performance; hypoxia.