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CHANGES OF IMMUNOLOGICAL PARAMETERS IN CONDITIONS OF INCREASED RESISTANCE TO BREATHING IN ATHLETES

YU. YU. BYALOVSKY (1), S. V. BULATETSKY (2) 1 -RYAZAN STATE MEDICAL UNIVERSITY NAMED AFTER ACADEMICIAN I.P. PAVLOV, RYAZAN, RUSSIA 2 -RYAZAN BRANCH OF MOSCOW UNIVERSITY OF THE DEPARTMENT OF THE INTERIOR OF THE RUSSIAN FEDERATION NAMED AFTER V.YA. KIKOTYA, RYAZAN, RUSSIA

Objective: to study the reactions of the immune system on the use of the increased breathing re-sistance.
Materials and Methods: the study involved 13 male professional judo athletes. The average age was 19,6 ± 3,2 years. Populations and subpopulations of lymphocytes were evaluated with the method of indirect immunofluorescence using monoclonal antibodies with CD3 +, CD4 +, CD8 +, CD16 +, CD20 +, with the assessmment of the immunoregulatory index CD4 + / CD8 +. Status of immunological resistance was determined by the percentage of phagocytosis, the number of active phagocytes, and the complement activity. The concentration of immunoglobulins G, A, M in serum was determined by the turbidimetric method.
Results: a significant decrease in the absolute number of leukocytes and lymphocytes in the peripheral blood (p <0,001) and decrease in the relative number of lymphocytes (p <0,05) was registered after exposure to 40% Pmmax. There was a significant decrease in the absolute number of lymphocytes classes CD4 +, CD16 +, CD3 +, CD20 +, (p <0,001); increase in population of lymphocytes CD8 + (p <0,05). An increase in the number of leukocytes in peripheral blood (p <0,0001); less prominent increase in the absolute lymphocyte count (p <0,05) and decrease in the relative lymphocyte count (p <0,05) was registered after exposure to the 60% Pmmax.
Conclusions: additional respiratory resistance within 20% Pmmax did not change the parameters of the immu-nological status of subjects. Resistive load value of 40% Pmmax caused immunosuppressive changes in lymphocyte population and in the parameters of nonspecific immunological resistance. Additional res-piratory resistance value of 60% Pmmax induced immunostimulating changes in lymphocyte popula-tion and in the parameters of nonspecific immunological resistance. .
Keywords: 
athletes; increased breathing resistance; immunological indicators.