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THE ROLE OF REACTIVE OXYGEN SPECIES IN ADAPTATION TO HIGH PHYSICAL WORKLOADS

K. P. BAZARIN FEDERAL SPORTS MEDICINE CENTER OF FEDERAL MEDICAL BIOLOGICAL AGENCY, MOSCOW, RUSSIA INSTITUTE OF PROFESSIONAL DEVELOPMENT OF FEDERAL MEDICAL BIOLOGICAL AGENCY, MOSCOW, RUSSIA

This review focused on the role of reactive oxygen species (ROS) in adaptation processes to high physical workload. ROS are major signaling
molecules that trigger the cascade of adaptation reactions in response to exercise. ROS are very effective regulators of adaptation to physical exertion if
its level is slightly greater than basal. Significant increase of ROS level due to decompensation in the antioxidant defense system is a maladaptive state.
Antioxidant drugs can increase athletic performance, but reduce the training effect at the same time.

Keywords: 
reactive oxygen; antioxidant system; sport; physical workload; adaptation; regulation mechanisms; antioxidant drugs.