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CELL TECHNOLOGIES IN SPORTS MEDICINE. PART 1: MUSCLE INJURIES

K. V. KOTENKO, I. I. EREMIN, A. A. PULIN, D. N. KURILENKOVA, I. I. NADELYAEVA STATE RESEARCH CENTER – BURNASYAN FEDERAL MEDICAL-BIOPHYSICAL CENTER, MOSCOW, RUSSIA
This review focuses on pathogenetic approaches in management of athlete’s muscle injuries, based on regenerative medicine technologies. Main methods and techniques of different etiology muscle injuries treatment such as: conservative anti-inflammatory treatment, surgical interventions, use of platelet rich plasma and alternative approaches based on principles of regenerative medicine; are reviewed and compared. Results of preclinical and clinical trials of different cell products and methods are provided. Safety and efficacy of cell products depending on stage and etiology of pathological process for use in sports medicine is discussed. Main applications of cell products in sports medicine are reviewed and discussed. Presented data analysis revealed that personified cell products derived from autologous fat tissue are the most perspective agent for the treatment of athletes muscle injuries, due to it’s therapeutic efficiency, safety and simplicity of preparation.
Keywords: 
regenerative medicine, personified medicine, stem cells, adipose tissue stromal-vascular fraction cells, multipotentmesenchymal stromal cells, sports medicine, muscle injury.