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ASSESSMENT OF THE ELEMENT AL ST ATUS OF AN INDIVIDUAL BY THE DISBALANCE COEFFICIENT ESTIMATED BY ICP-MS ANALYZING OF HU MANS’ BIO MATERIALS

E. B. PODGORNAYA, O. I. BUROVA, A. S. RADILOV, V. R. REMBOVSKII, S. D. PLOTNIKOVA RESEARCH INSTITUTE OF HYGIENE, OCCUPATIONAL PATHOLOGY AND HUMAN ECOLOGY (RIHOPHE), ST-PETERSBURG, RUSSIA

Objective: to demonstrate the need for a comprehensive assessment of the element status in biomaterials, and to develop a system of complex diagnostics. Materials and methods: elemental composition (Na, Mg, K, Ca, zn, As, Se, Cd) in blood, hair and urine was investigated by ICP-MS method. The groups were divided according to their levels of sports skill: the master of sports of the international class (33 in biathlon), candidates for master of sports and master of sports (58 skiers), and 29 patients, not involved in sports; the average age of the groups was 25±5 years.
Results: it was shown that the element status of an athlete is associated with the level of their skills and the level of the phisical loads; quartiles ranks of concentrations in the blood of essential macronutrients: Na, Mg, K, Ca, and trace elements: zn, Se, conditionally essential: As, Cd decreased in samples from the control group of sedentaty males to a group of elite athletes, reaching compensatory optimally-functional state; to assess the elemental balance the normalizing – coefficient of disbalance (Кd) index was proposed; five states of the elemental status in total combination were allocated in accordance to classes of the Кd elements in biomaterials: normal, prenosological deficit, prenosological excess, pathological state deficit, pathological state excess; cluster analysis of the status of the elemental balance of three biomateials showed significant differences in the profiles of selected groups depending on the intensity of physical activity.
Conclusions: the need for a comprehensive assessment of the element status in the aggregate values of the coefficient of disbalance was shown; the system of complex diagnostics, which allows to detect changes of the elemental status determined by changes in adaptation and the state of overtraining, and to develop an algorithm of recovery procedures for the correction of functional state was proposed.
Keywords: 
athletes; adaptation; the element balance; the element status; mass spectrometry with inductive-connected plasma; cluster analysis; coefficient of disbalance.