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PRE-CLINICAL DEVELOPMENT OF THE «ANTISTRESS» (DRUG) FOR ANXIOLYTIC ACTIVITY

E. S. TOKAEV (2), A. S. KINZIRSKY (1), E. A. NEKRASOV (2), A. A. KHASANOV (2), I. S. KRASNOVA (3) 1 -INSTITUTE OF PHYSIOLOGICALLY ACTIVE SUBSTANCES OF RUSSIAN ACADEMY OF SCIENCES, CHERNOGOLOVKA, RUSSIA 2 -JSC « ACADEMY-T», MOSCOW, RUSSIA 3THE MOSCOW STATE UNIVERSITY OF FOOD PRODUCTION, MOSCOW, RUSSIA

Objective: Preclinical evaluation of anti-anxiety and anti-stress activity, and side effect on locomotor functions of the new substance «Antistress». Materials and Methods: The objective of this research work were: a specialized product for athletes «Anti-stress», consisting of a mixture of extracts of grape and apple Vinitroks extract citrus Serentso, glycine, 5-hydroxytryptophan, vitamin B6, vitamin B8; imipramine; extract citrus Serenzo. The effect of selected substances on the level of situational anxiety, muscle tone and endurance of rats were investigated by standard pharmacological methods.
Results: It was shown that “Antistress” reliever dose of 16 mg/kg has the greatest anxiolytic activity. Similar properties were found in forced helplessness tests: groups hadn’t statistically significant differences in the first day of the test, there was a significant reduction in the beginning of immobility in comparison with the first day in groups of rats treated with Anti-stress (16 mg/kg), Serenzo (0.55 mg/kg) and imipramine (10 mg/kg) on the second day of the test.
Conclusions: It was shown that the “Antistress” moderately reduces situational anxiety in rats and has adaptogenic effects.
Keywords: 
preclinical research, stress, adaptogenic properties, situational anxiety, anxiolytic activity, forced helpless tests, sport nutrition.